Assay Detail
Functional
CHEMBL902548
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of T cell activation in human mixed lymphocyte reaction
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.09 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL248081 | — | — | 1 | 6.92 |
| CHEMBL248080 | — | — | 1 | 6.86 |
| CHEMBL247880 | — | — | 1 | 6.64 |
| CHEMBL247468 | — | — | 1 | 6.64 |
| CHEMBL247677 | — | — | 1 | 6.47 |
| CHEMBL248286 | — | — | 1 | 6.44 |
| CHEMBL247878 | — | — | 1 | 6.36 |
| CHEMBL247479 | — | — | 1 | 6.33 |
| CHEMBL247866 | — | — | 1 | 6.27 |
| CHEMBL247480 | — | — | 1 | 6.17 |
| CHEMBL399212 | — | — | 1 | 6.08 |
| CHEMBL247667 | — | — | 1 | 5.78 |
| CHEMBL247272 | — | — | 1 | 5.77 |
| CHEMBL247068 | — | — | 1 | 5.67 |
| CHEMBL399008 | — | — | 1 | 5.62 |
| CHEMBL247469 | — | — | 1 | 5.61 |
| CHEMBL248079 | — | — | 1 | 5.51 |
| CHEMBL394490 | — | — | 1 | 5.49 |
| CHEMBL247070 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL248081 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL248080 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL247880 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL247468 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL247677 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL248286 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL247878 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL247479 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL247866 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL247480 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL399212 | — | IC50 | = | 825.0 | nM | 6.08 |
| CHEMBL247667 | — | IC50 | = | 1672.0 | nM | 5.78 |
| CHEMBL247272 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL247068 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL399008 | — | IC50 | = | 2376.0 | nM | 5.62 |
| CHEMBL247469 | — | IC50 | = | 2452.0 | nM | 5.61 |
| CHEMBL248079 | — | IC50 | = | 3084.0 | nM | 5.51 |
| CHEMBL394490 | — | IC50 | = | 3223.0 | nM | 5.49 |
| CHEMBL247070 | — | IC50 | = | 8950.0 | nM | 5.05 |