Assay Detail
Functional
CHEMBL902549
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Inhibition of anti-CD3/CD28-induced IL2 secretion in human T cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.13 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL247479 | — | — | 1 | 6.92 |
| CHEMBL399212 | — | — | 1 | 6.71 |
| CHEMBL247866 | — | — | 1 | 6.70 |
| CHEMBL247677 | — | — | 1 | 6.53 |
| CHEMBL247468 | — | — | 1 | 6.37 |
| CHEMBL247480 | — | — | 1 | 6.36 |
| CHEMBL248286 | — | — | 1 | 6.33 |
| CHEMBL247272 | — | — | 1 | 6.16 |
| CHEMBL247878 | — | — | 1 | 5.62 |
| CHEMBL247070 | — | — | 1 | 5.62 |
| CHEMBL394490 | — | — | 1 | 5.58 |
| CHEMBL399008 | — | — | 1 | 5.49 |
| CHEMBL247667 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL247479 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL399212 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL247866 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL247677 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL247468 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL247480 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL248286 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL247272 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL247878 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL247070 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL394490 | — | IC50 | = | 2634.0 | nM | 5.58 |
| CHEMBL399008 | — | IC50 | = | 3257.0 | nM | 5.49 |
| CHEMBL247667 | — | IC50 | = | 5719.0 | nM | 5.24 |