Assay Detail
Binding
CHEMBL902628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human mineralocorticoid receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
(S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.41 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235206 | — | — | 1 | 9.31 |
| CHEMBL235209 | — | — | 1 | 8.81 |
| CHEMBL391231 | — | — | 1 | 8.65 |
| CHEMBL1393 | SPIRONOLACTONE | 4.0 | 1 | 8.63 |
| CHEMBL391439 | — | — | 1 | 8.12 |
| CHEMBL237122 | EPIERENONE | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235206 | — | Ki | = | 0.494 | nM | 9.31 |
| CHEMBL235209 | — | Ki | = | 1.56 | nM | 8.81 |
| CHEMBL391231 | — | Ki | = | 2.25 | nM | 8.65 |
| CHEMBL1393 | SPIRONOLACTONE | Ki | = | 2.323 | nM | 8.63 |
| CHEMBL391439 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL237122 | EPIERENONE | Ki | = | 124.0 | nM | 6.91 |