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Assay Detail

CHEMBL902633

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human IMPDH 1
9
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
Chen L, Wilson D, Jayaram HN, Pankiewicz KW.
J Med Chem (2007) 50 : 6685 -6691
PubMed 18038969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 6.36 7.40
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 7.40
CHEMBL238461 MYCOPHENOLIC HYDROXAMIC ACID 1 7.16
CHEMBL394276 TIAZOFURIN ADENINE DINUCLEOTIDE 1 7.00
CHEMBL392178 1 6.40
CHEMBL238905 1 5.68
CHEMBL239105 1 5.55
CHEMBL429090 1 5.30
CHEMBL98 VORINOSTAT 4.0 1 -
CHEMBL238904 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL866 MYCOPHENOLIC ACID Ki = 40.0 nM 7.40
CHEMBL238461 MYCOPHENOLIC HYDROXAMIC ACID Ki = 70.0 nM 7.16
CHEMBL394276 TIAZOFURIN ADENINE DINUCLEOTIDE Ki = 100.0 nM 7.00
CHEMBL392178 Ki = 400.0 nM 6.40
CHEMBL238905 Ki = 2070.0 nM 5.68
CHEMBL239105 Ki = 2830.0 nM 5.55
CHEMBL429090 Ki = 5000.0 nM 5.30
CHEMBL98 VORINOSTAT Activity - -
CHEMBL238904 Activity - -