Assay Detail
Binding
CHEMBL902667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum recombinant AChE by Ellman's method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.02 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 9.09 |
| CHEMBL238230 | — | — | 1 | 8.74 |
| CHEMBL440983 | — | — | 1 | 8.18 |
| CHEMBL235014 | — | — | 1 | 7.71 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL238230 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL440983 | — | IC50 | = | 6.65 | nM | 8.18 |
| CHEMBL235014 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL95 | TACRINE | IC50 | = | 424.0 | nM | 6.37 |