Assay Detail
Binding
CHEMBL902668
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Inhibition of human serum recombinant BChE by Ellman's method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.85 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440983 | — | — | 1 | 8.26 |
| CHEMBL32823 | — | — | 1 | 8.25 |
| CHEMBL238230 | — | — | 1 | 7.95 |
| CHEMBL235014 | — | — | 1 | 7.46 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440983 | — | IC50 | = | 5.44 | nM | 8.26 |
| CHEMBL32823 | — | IC50 | = | 5.66 | nM | 8.25 |
| CHEMBL238230 | — | IC50 | = | 11.3 | nM | 7.95 |
| CHEMBL235014 | — | IC50 | = | 35.1 | nM | 7.46 |
| CHEMBL95 | TACRINE | IC50 | = | 45.8 | nM | 7.34 |