Assay Detail
Binding
CHEMBL902751
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Inhibition of human thrombin
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.47 | 6.54 |
| Ki | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL238707 | — | — | 1 | 6.54 |
| CHEMBL391968 | — | — | 1 | 6.41 |
| CHEMBL214814 | — | — | 1 | 6.11 |
| CHEMBL239331 | — | — | 1 | 6.11 |
| CHEMBL393979 | — | — | 1 | 5.95 |
| CHEMBL239118 | — | — | 1 | 5.63 |
| CHEMBL239535 | — | — | 1 | 5.62 |
| CHEMBL239536 | — | — | 1 | 5.42 |
| CHEMBL391344 | — | — | 1 | 5.09 |
| CHEMBL238491 | — | — | 1 | 4.92 |
| CHEMBL238913 | — | — | 1 | 4.77 |
| CHEMBL393591 | — | — | 1 | 4.77 |
| CHEMBL238708 | — | — | 1 | 4.70 |
| CHEMBL239747 | — | — | 1 | 4.49 |
| CHEMBL391969 | — | — | 1 | - |
| CHEMBL238493 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL238707 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL391968 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL214814 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL239331 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL393979 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL239118 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL239535 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL239536 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL391344 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL238491 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL238913 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL393591 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL238708 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL239747 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL391969 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL238493 | — | IC50 | = | 125000.0 | nM | - |