Assay Detail

CHEMBL902994

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Functional

Antiviral activity against HIV 589.000049 by viral replication assay

ChEMBL ↗

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Target

Human immunodeficiency virus (CHEMBL613758) ↗

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Primary target Human immunodeficiency virus

CHEMBL613758

Anchored from Assay target.

Protein identity Human immunodeficiency virus

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Human immunodeficiency virus
Confidence	1 — Organism
Curated By	Intermediate

Target

Human immunodeficiency virus (CHEMBL613758) ↗

Type	ORGANISM
Organism	Human immunodeficiency virus

Publication

Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group.

Lu RJ, Tucker JA, Zinevitch T, Kirichenko O, Konoplev V, Kuznetsova S, Sviridov S, Pickens J, Tandel S, Brahmachary E, Yang Y, Wang J, Freel S, Fisher S, Sullivan A, Zhou J, Stanfield-Oakley S, Greenberg M, Bolognesi D, Bray B, Koszalka B, Jeffs P, Khasanov A, Ma YA, Jeffries C, Liu C, Proskurina T, Zhu T, Chucholowski A, Li R, Sexton C.
J Med Chem (2007) 50 : 6535 -6544
PubMed 18052117 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.78	8.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL337301	—	—	1	8.22
CHEMBL238115	—	—	1	7.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL337301	—	IC50	=	6.0	nM	8.22
CHEMBL238115	—	IC50	=	46.0	nM	7.34