Assay Detail
Functional
CHEMBL903138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 with reverse transcriptase K103N mutation in MT4 cells after 5 days by MTT method
59
Total Activities
59
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 59 | 5.41 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235937 | — | — | 1 | 6.58 |
| CHEMBL237218 | — | — | 1 | 6.26 |
| CHEMBL237219 | — | — | 1 | 6.18 |
| CHEMBL391222 | — | — | 1 | 6.14 |
| CHEMBL237027 | — | — | 1 | 6.09 |
| CHEMBL235099 | — | — | 1 | 6.04 |
| CHEMBL236148 | — | — | 1 | 5.99 |
| CHEMBL237607 | — | — | 1 | 5.72 |
| CHEMBL391114 | — | — | 1 | 5.61 |
| CHEMBL237604 | — | — | 1 | 5.46 |
| CHEMBL237411 | — | — | 1 | 5.38 |
| CHEMBL237212 | — | — | 1 | 5.21 |
| CHEMBL237410 | — | — | 1 | 5.21 |
| CHEMBL398992 | — | — | 1 | 5.19 |
| CHEMBL237026 | — | — | 1 | 5.18 |
| CHEMBL237210 | — | — | 1 | 5.17 |
| CHEMBL398807 | — | — | 1 | 5.17 |
| CHEMBL237403 | — | — | 1 | 5.16 |
| CHEMBL237030 | — | — | 1 | 5.11 |
| CHEMBL237023 | — | — | 1 | 5.05 |
| CHEMBL237215 | — | — | 1 | 5.03 |
| CHEMBL393310 | — | — | 1 | 4.99 |
| CHEMBL237029 | — | — | 1 | 4.99 |
| CHEMBL391221 | — | — | 1 | 4.97 |
| CHEMBL393311 | — | — | 1 | 4.95 |
| CHEMBL237405 | — | — | 1 | 4.93 |
| CHEMBL235901 | — | — | 1 | 4.92 |
| CHEMBL238029 | — | — | 1 | 4.91 |
| CHEMBL430174 | — | — | 1 | - |
| CHEMBL396664 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235937 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL237218 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL237219 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL391222 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL237027 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL235099 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL236148 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL237607 | — | EC50 | = | 1923.0 | nM | 5.72 |
| CHEMBL391114 | — | EC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL237604 | — | EC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL237411 | — | EC50 | = | 4130.0 | nM | 5.38 |
| CHEMBL237212 | — | EC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL237410 | — | EC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL398992 | — | EC50 | = | 6470.0 | nM | 5.19 |
| CHEMBL237026 | — | EC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL237210 | — | EC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL398807 | — | EC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL237403 | — | EC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL237030 | — | EC50 | = | 7780.0 | nM | 5.11 |
| CHEMBL237023 | — | EC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL237215 | — | EC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL393310 | — | EC50 | = | 10220.0 | nM | 4.99 |
| CHEMBL237029 | — | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL391221 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL393311 | — | EC50 | = | 11180.0 | nM | 4.95 |
| CHEMBL237405 | — | EC50 | = | 11630.0 | nM | 4.93 |
| CHEMBL235901 | — | EC50 | = | 11880.0 | nM | 4.92 |
| CHEMBL238029 | — | EC50 | = | 12210.0 | nM | 4.91 |
| CHEMBL235707 | — | EC50 | > | 54820.0 | nM | - |
| CHEMBL237165 | — | EC50 | > | 190.0 | nM | - |
| CHEMBL393128 | — | EC50 | > | 26430.0 | nM | - |
| CHEMBL235714 | — | EC50 | > | 40970.0 | nM | - |
| CHEMBL391115 | — | EC50 | > | 11650.0 | nM | - |
| CHEMBL235715 | — | EC50 | > | 3930.0 | nM | - |
| CHEMBL235936 | — | EC50 | > | 11280.0 | nM | - |
| CHEMBL398789 | — | EC50 | > | 59100.0 | nM | - |
| CHEMBL236149 | — | EC50 | > | 5750.0 | nM | - |
| CHEMBL236355 | — | EC50 | > | 27230.0 | nM | - |
| CHEMBL400028 | — | EC50 | > | 56180.0 | nM | - |
| CHEMBL237599 | — | EC50 | > | 54470.0 | nM | - |
| CHEMBL237603 | — | EC50 | > | 58550.0 | nM | - |
| CHEMBL235098 | — | EC50 | > | 55870.0 | nM | - |
| CHEMBL428719 | — | EC50 | > | 54350.0 | nM | - |
| CHEMBL235067 | — | EC50 | > | 32140.0 | nM | - |
| CHEMBL237032 | — | EC50 | > | 79870.0 | nM | - |
| CHEMBL237609 | — | EC50 | > | 66310.0 | nM | - |
| CHEMBL237025 | — | EC50 | > | 55550.0 | nM | - |
| CHEMBL237213 | — | EC50 | > | 62190.0 | nM | - |
| CHEMBL396664 | — | EC50 | > | 59520.0 | nM | - |
| CHEMBL430174 | — | EC50 | > | 60100.0 | nM | - |