Assay Detail
Binding
CHEMBL903157
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Inhibition of VZV-TK catalyzed dThd phosphorylation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and antiviral activity of the carbocyclic analogue of the highly potent and selective anti-VZV bicyclo furano pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.19 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 5.89 |
| CHEMBL344738 | CF1743 | — | 1 | 5.31 |
| CHEMBL268634 | — | — | 1 | 4.36 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL344738 | CF1743 | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL268634 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 100000.0 | nM | - |