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Assay Detail

CHEMBL903316

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p56lck SH2 domain by ELISA
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain.
Park SH, Oh HS, Kang MA, Cho H, Prasad JB, Won J, Lee KH.
Bioorg Med Chem (2007) 15 : 3938 -3950
PubMed 17418581 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 4.64 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL394398 1 5.75
CHEMBL241193 1 4.89
CHEMBL241192 1 4.82
CHEMBL241404 1 4.72
CHEMBL115421 1 4.70
CHEMBL241190 1 4.68
CHEMBL241403 1 4.68
CHEMBL324842 ROSMARINIC ACID 1 4.62
CHEMBL396074 1 4.50
CHEMBL116952 1 4.15
CHEMBL241405 METHYL ROSMARINATE 1 4.10
CHEMBL241613 ETHYL ROSMARINATE 1 4.04
CHEMBL241615 1 -
CHEMBL241820 1 -
CHEMBL393974 1 -
CHEMBL393975 1 -
CHEMBL351042 1 -
CHEMBL145 CAFFEIC ACID 3.0 1 -
CHEMBL238631 1 -
CHEMBL238416 1 -
CHEMBL238415 1 -
CHEMBL238414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL394398 IC50 = 1800.0 nM 5.75
CHEMBL241193 IC50 = 13000.0 nM 4.89
CHEMBL241192 IC50 = 15000.0 nM 4.82
CHEMBL241404 IC50 = 19000.0 nM 4.72
CHEMBL115421 IC50 = 20000.0 nM 4.70
CHEMBL241190 IC50 = 21000.0 nM 4.68
CHEMBL241403 IC50 = 21000.0 nM 4.68
CHEMBL324842 ROSMARINIC ACID IC50 = 24000.0 nM 4.62
CHEMBL396074 IC50 = 32000.0 nM 4.50
CHEMBL116952 IC50 = 71000.0 nM 4.15
CHEMBL241405 METHYL ROSMARINATE IC50 = 80000.0 nM 4.10
CHEMBL241613 ETHYL ROSMARINATE IC50 = 91000.0 nM 4.04
CHEMBL241615 IC50 = 145000.0 nM -
CHEMBL241820 IC50 = 110000.0 nM -
CHEMBL393974 IC50 = 127000.0 nM -
CHEMBL393975 IC50 > 500000.0 nM -
CHEMBL351042 IC50 > 500000.0 nM -
CHEMBL145 CAFFEIC ACID IC50 > 500000.0 nM -
CHEMBL238631 IC50 > 500000.0 nM -
CHEMBL238416 IC50 > 500000.0 nM -
CHEMBL238415 IC50 > 500000.0 nM -
CHEMBL238414 IC50 > 500000.0 nM -