Compound Detail
CHEMBL241190
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Basic Information
| ChEMBL ID | CHEMBL241190 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GPZFXSWMDFBRGS-UXONFWTHSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
359.3
MW (Da)
1.33
ALogP
6
HBA
6
HBD
147.3
PSA (Ų)
0.34
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | IC50 | 5.24 | 5.24 | 5700.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | IC50 | = | 5700.0 | nM | 5.24 | Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs b... | 29706525 |
| Unchecked | IC50 | = | 21000.0 | nM | 4.68 | Inhibition of p56lck SH2 domain by ELISA | 17418581 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29706525 | 10.1016/j.bmc.2018.04.044 | Amyloid-beta precursor protein | 3 |
| 17418581 | 10.1016/j.bmc.2006.06.059 | Unchecked | 1 |
| 17418581 | 10.1016/j.bmc.2006.06.059 | Jurkat | 1 |
| 17418581 | 10.1016/j.bmc.2006.06.059 | No relevant target | 1 |
| 37856864 | 10.1021/acs.jnatprod.3c00465 | RAW264.7 | 1 |
| 38740144 | 10.1016/j.bmcl.2024.129788 | Amyloid-beta precursor protein | 1 |
| 38740144 | 10.1016/j.bmcl.2024.129788 | No relevant target | 1 |
| 38740144 | 10.1016/j.bmcl.2024.129788 | PC-12 | 1 |
Data from ChEMBL 36 via Core Engine