Assay Detail
Binding
CHEMBL4122325
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Inhibition of amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by thioflavin T fluorescence assay
20
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationship of clovamide and its related compounds for the inhibition of amyloid β aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.89 | 5.80 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115421 | — | — | 2 | 5.80 |
| CHEMBL2296789 | N-CAFFEOYL-DOPA METHYL ESTER | — | 2 | 5.31 |
| CHEMBL241190 | — | — | 2 | 5.24 |
| CHEMBL4127090 | — | — | 2 | 5.06 |
| CHEMBL4126558 | — | — | 2 | 4.64 |
| CHEMBL2392127 | — | — | 2 | 4.14 |
| CHEMBL4126715 | — | — | 2 | 4.06 |
| CHEMBL4127947 | — | — | 1 | - |
| CHEMBL4129983 | — | — | 1 | - |
| CHEMBL4125745 | — | — | 1 | - |
| CHEMBL4129190 | — | — | 1 | - |
| CHEMBL3276007 | — | — | 1 | - |
| CHEMBL4126073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115421 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2296789 | N-CAFFEOYL-DOPA METHYL ESTER | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL241190 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4127090 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4126558 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL2392127 | — | IC50 | = | 72900.0 | nM | 4.14 |
| CHEMBL4126715 | — | IC50 | = | 87800.0 | nM | 4.06 |
| CHEMBL4126558 | — | Inhibition | - | % | - | |
| CHEMBL4126073 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4126715 | — | Inhibition | - | % | - | |
| CHEMBL2392127 | — | Inhibition | - | % | - | |
| CHEMBL3276007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4129190 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2296789 | N-CAFFEOYL-DOPA METHYL ESTER | Inhibition | - | % | - | |
| CHEMBL4125745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4129983 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL241190 | — | Inhibition | - | % | - | |
| CHEMBL115421 | — | Inhibition | - | % | - | |
| CHEMBL4127947 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4127090 | — | Inhibition | - | % | - |