Assay Detail
Functional
CHEMBL903344
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Growth inhibition of mouse L929 cells by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.69 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL241106 | ARCHAZOLID A | — | 1 | 9.09 |
| CHEMBL411767 | ARCHAZOLID B | — | 1 | 8.96 |
| CHEMBL396004 | — | — | 1 | 7.85 |
| CHEMBL395846 | — | — | 1 | 6.54 |
| CHEMBL395845 | — | — | 1 | 6.03 |
| CHEMBL396090 | DEHYDROARCHAZOLID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL241106 | ARCHAZOLID A | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL411767 | ARCHAZOLID B | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL396004 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL395846 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL395845 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL396090 | DEHYDROARCHAZOLID | IC50 | > | 5000.0 | nM | - |