Assay Detail
Functional
CHEMBL903519
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Antiproliferative activity against human N87 cells
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-N87 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.11 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL246284 | — | — | 1 | 7.08 |
| CHEMBL428046 | — | — | 1 | 6.89 |
| CHEMBL245278 | — | — | 1 | 6.89 |
| CHEMBL396079 | — | — | 1 | 6.62 |
| CHEMBL245869 | — | — | 1 | 6.48 |
| CHEMBL427671 | — | — | 1 | 6.42 |
| CHEMBL247127 | — | — | 1 | 6.26 |
| CHEMBL246493 | — | — | 1 | 6.21 |
| CHEMBL245667 | — | — | 1 | 6.19 |
| CHEMBL394495 | — | — | 1 | 6.18 |
| CHEMBL246072 | — | — | 1 | 6.14 |
| CHEMBL246073 | — | — | 1 | 6.01 |
| CHEMBL246694 | — | — | 1 | 5.77 |
| CHEMBL246491 | — | — | 1 | 5.77 |
| CHEMBL394333 | — | — | 1 | 5.77 |
| CHEMBL395591 | — | — | 1 | 5.70 |
| CHEMBL245277 | — | — | 1 | 5.66 |
| CHEMBL246492 | — | — | 1 | 5.52 |
| CHEMBL395883 | — | — | 1 | 5.47 |
| CHEMBL246276 | — | — | 1 | 5.13 |
| CHEMBL394056 | — | — | 1 | - |
| CHEMBL246489 | — | — | 1 | - |
| CHEMBL397122 | — | — | 1 | - |
| CHEMBL394057 | — | — | 1 | - |
| CHEMBL245867 | — | — | 1 | - |
| CHEMBL245868 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL246284 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL428046 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL245278 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL396079 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL245869 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL427671 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL247127 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL246493 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL245667 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL394495 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL246072 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL246073 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL246694 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL246491 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL394333 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL395591 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL245277 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL246492 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL395883 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL246276 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL394056 | — | IC50 | - | — | - | |
| CHEMBL246489 | — | IC50 | - | — | - | |
| CHEMBL397122 | — | IC50 | - | — | - | |
| CHEMBL394057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL245867 | — | IC50 | - | — | - | |
| CHEMBL245868 | — | IC50 | - | — | - |