Assay Detail
Binding
CHEMBL903617
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Inhibition of JAK3
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.14 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240432 | — | — | 1 | 7.60 |
| CHEMBL240429 | — | — | 1 | 7.58 |
| CHEMBL240430 | — | — | 1 | 7.50 |
| CHEMBL437754 | — | — | 1 | 7.43 |
| CHEMBL239590 | — | — | 1 | 7.36 |
| CHEMBL393596 | — | — | 1 | 7.15 |
| CHEMBL427687 | — | — | 1 | 7.10 |
| CHEMBL240431 | — | — | 1 | 6.96 |
| CHEMBL392990 | — | — | 1 | 6.85 |
| CHEMBL239591 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240432 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL240429 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL240430 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL437754 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL239590 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL393596 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL427687 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL240431 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL392990 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL239591 | — | IC50 | = | 1400.0 | nM | 5.85 |