Assay Detail
Functional
CHEMBL903618
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Inhibition of anti-CD3/CD28-induced IL2 secretion in human T cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.21 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240430 | — | — | 1 | 6.89 |
| CHEMBL239590 | — | — | 1 | 6.60 |
| CHEMBL240432 | — | — | 1 | 6.33 |
| CHEMBL393596 | — | — | 1 | 6.29 |
| CHEMBL240431 | — | — | 1 | 6.19 |
| CHEMBL247272 | — | — | 1 | 6.15 |
| CHEMBL392990 | — | — | 1 | 5.92 |
| CHEMBL240429 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240430 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL239590 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL240432 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL393596 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL240431 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL247272 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL392990 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL240429 | — | IC50 | = | 5200.0 | nM | 5.28 |