Assay Detail
Functional
CHEMBL903666
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 LAI replication in human PBMC after 5 days
11
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of novel 5(H)-phenanthridin-6-ones, 5(H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.73 | 9.14 |
| EC90 | 5 | - | - |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 2 | 9.14 |
| CHEMBL226485 | — | — | 2 | 5.10 |
| CHEMBL375484 | — | — | 2 | 4.58 |
| CHEMBL389930 | — | — | 2 | 4.08 |
| CHEMBL226490 | — | — | 2 | - |
| CHEMBL19977 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 0.73 | nM | 9.14 |
| CHEMBL226485 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL375484 | — | EC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL389930 | — | EC50 | = | 83700.0 | nM | 4.08 |
| CHEMBL129 | ZIDOVUDINE | EC90 | = | 0.019 | uM | - |
| CHEMBL226490 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL226490 | — | EC90 | > | 100.0 | uM | - |
| CHEMBL389930 | — | EC90 | > | 100.0 | uM | - |
| CHEMBL375484 | — | EC90 | > | 100.0 | uM | - |
| CHEMBL226485 | — | EC90 | = | 72.8 | uM | - |
| CHEMBL19977 | — | Activity | - | — | - |