Assay Detail
Functional
CHEMBL903820
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Inhibition of adenosine kinase in intact cells assessed as adenosine phosphorylation
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.61 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225729 | — | — | 1 | 7.41 |
| CHEMBL225671 | — | — | 1 | 7.24 |
| CHEMBL216697 | — | — | 1 | 7.17 |
| CHEMBL225672 | — | — | 1 | 7.10 |
| CHEMBL225670 | — | — | 1 | 7.08 |
| CHEMBL225679 | — | — | 1 | 7.06 |
| CHEMBL226486 | — | — | 1 | 7.00 |
| CHEMBL225886 | — | — | 1 | 6.96 |
| CHEMBL375255 | — | — | 1 | 6.92 |
| CHEMBL449402 | — | — | 1 | 6.91 |
| CHEMBL225727 | — | — | 1 | 6.88 |
| CHEMBL376844 | — | — | 1 | 6.79 |
| CHEMBL225782 | — | — | 1 | 6.78 |
| CHEMBL438476 | — | — | 1 | 6.70 |
| CHEMBL225680 | — | — | 1 | 6.70 |
| CHEMBL226428 | — | — | 1 | 6.67 |
| CHEMBL225678 | — | — | 1 | 6.67 |
| CHEMBL387486 | — | — | 1 | 6.64 |
| CHEMBL226392 | — | — | 1 | 6.62 |
| CHEMBL386316 | — | — | 1 | 6.60 |
| CHEMBL225833 | — | — | 1 | 6.56 |
| CHEMBL225887 | — | — | 1 | 6.48 |
| CHEMBL226505 | — | — | 1 | 6.48 |
| CHEMBL225696 | — | — | 1 | 6.48 |
| CHEMBL427272 | — | — | 1 | 6.46 |
| CHEMBL226515 | — | — | 1 | 6.30 |
| CHEMBL389409 | — | — | 1 | 6.26 |
| CHEMBL225695 | — | — | 1 | 6.22 |
| CHEMBL225834 | — | — | 1 | 6.16 |
| CHEMBL225633 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225729 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL225671 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL216697 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL225672 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL225670 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL225679 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL226486 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL225886 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL375255 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL449402 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL225727 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL376844 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL225782 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL225680 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL438476 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL226428 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL225678 | — | IC50 | = | 215.0 | nM | 6.67 |
| CHEMBL387486 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL226392 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL386316 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL225833 | — | IC50 | = | 275.0 | nM | 6.56 |
| CHEMBL225887 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL226505 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL225696 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL427272 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL226515 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL389409 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL225695 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL225834 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL225633 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL225694 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL388192 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL225781 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL390827 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL387630 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL225706 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL225705 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225707 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225877 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL375060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225722 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225773 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL226503 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL387629 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL226451 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL226450 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225774 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL216119 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL225728 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL226504 | — | IC50 | > | 1000.0 | nM | - |