Assay Detail
Binding
CHEMBL903889
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Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | EOL1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.95 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL226184 | — | — | 1 | 6.57 |
| CHEMBL226183 | — | — | 1 | 6.40 |
| CHEMBL376787 | — | — | 1 | 6.22 |
| CHEMBL7724 | AG1295 | — | 1 | 5.96 |
| CHEMBL226182 | — | — | 1 | 5.77 |
| CHEMBL225827 | — | — | 1 | 5.75 |
| CHEMBL226417 | — | — | 1 | 5.46 |
| CHEMBL225826 | — | — | 1 | 5.44 |
| CHEMBL226131 | — | — | 1 | - |
| CHEMBL389234 | — | — | 1 | - |
| CHEMBL225825 | — | — | 1 | - |
| CHEMBL225772 | — | — | 1 | - |
| CHEMBL389233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL226184 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL226183 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL376787 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL7724 | AG1295 | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL226182 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL225827 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL226417 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL225826 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL226131 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL389234 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL225825 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL225772 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL389233 | — | IC50 | > | 30000.0 | nM | - |