Compound Detail
CHEMBL226182
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Basic Information
| ChEMBL ID | CHEMBL226182 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UACDZFCKAGJOFV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
378.3
MW (Da)
4.26
ALogP
7
HBA
0
HBD
96.0
PSA (Ų)
0.30
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor beta | IC50 | = | 700.0 | nM | 6.16 | Inhibition of endogenous PDGFRbeta autophosphorylation in Swiss 3T3 fibroblasts | 17210255 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of endogenous FLT3 autophosphorylation in EOL1 cells | 17210255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17210255 | 10.1016/j.bmc.2006.12.011 | Platelet-derived growth factor receptor beta | 1 |
| 17210255 | 10.1016/j.bmc.2006.12.011 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine