Assay Detail
Binding
CHEMBL903950
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Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide production by hemoglobin capture assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.48 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375895 | — | — | 1 | 5.37 |
| CHEMBL228077 | — | — | 1 | 4.77 |
| CHEMBL226390 | — | — | 1 | 4.26 |
| CHEMBL226445 | — | — | 1 | 4.24 |
| CHEMBL226448 | — | — | 1 | 4.19 |
| CHEMBL375943 | — | — | 1 | 4.05 |
| CHEMBL375056 | — | — | 1 | - |
| CHEMBL226499 | — | — | 1 | - |
| CHEMBL376145 | — | — | 1 | - |
| CHEMBL226447 | — | — | 1 | - |
| CHEMBL226446 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375895 | — | Ki | = | 4280.0 | nM | 5.37 |
| CHEMBL228077 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL226390 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL226445 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL226448 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL375943 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL375056 | — | Ki | = | 515000.0 | nM | - |
| CHEMBL226499 | — | Ki | = | 242000.0 | nM | - |
| CHEMBL376145 | — | Ki | = | 124000.0 | nM | - |
| CHEMBL226447 | — | Ki | = | 202000.0 | nM | - |
| CHEMBL226446 | — | Ki | = | 535000.0 | nM | - |