Assay Detail
Binding
CHEMBL904077
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Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.78 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.51 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.51 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL226438 | — | — | 1 | 6.06 |
| CHEMBL227567 | — | — | 1 | 6.05 |
| CHEMBL227565 | — | — | 1 | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL226439 | — | — | 1 | 5.39 |
| CHEMBL228176 | — | — | 1 | 5.23 |
| CHEMBL442057 | — | — | 1 | 5.05 |
| CHEMBL376841 | — | — | 1 | 5.05 |
| CHEMBL388982 | — | — | 1 | 5.01 |
| CHEMBL228229 | — | — | 1 | 5.01 |
| CHEMBL227566 | — | — | 1 | 5.00 |
| CHEMBL388309 | — | — | 1 | 4.99 |
| CHEMBL226149 | — | — | 1 | - |
| CHEMBL373721 | — | — | 1 | - |
| CHEMBL514138 | CGS-27023A | — | 1 | - |
| CHEMBL228230 | — | — | 1 | - |
| CHEMBL228231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL77517 | INDISULAM | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL226438 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL227567 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL227565 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL226439 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL228176 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL442057 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL376841 | — | Ki | = | 8910.0 | nM | 5.05 |
| CHEMBL388982 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL228229 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL227566 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL388309 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL226149 | — | Ki | = | 490000.0 | nM | - |
| CHEMBL373721 | — | Ki | = | 156000.0 | nM | - |
| CHEMBL514138 | CGS-27023A | Ki | = | 281000.0 | nM | - |
| CHEMBL228230 | — | Ki | = | 520000.0 | nM | - |
| CHEMBL228231 | — | Ki | = | 435000.0 | nM | - |