Assay Detail
Binding
CHEMBL904224
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Inhibition of yeast alpha glucosidase at pH 6.8
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of xanthone derivatives with extended pi-systems as alpha-glucosidase inhibitors: insight into the probable binding mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.73 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227226 | — | — | 1 | 5.24 |
| CHEMBL227227 | — | — | 1 | 5.10 |
| CHEMBL227224 | — | — | 1 | 5.03 |
| CHEMBL387528 | — | — | 1 | 4.70 |
| CHEMBL227225 | — | — | 1 | 4.58 |
| CHEMBL226546 | — | — | 1 | 4.56 |
| CHEMBL226547 | — | — | 1 | 4.50 |
| CHEMBL226595 | — | — | 1 | 4.46 |
| CHEMBL387529 | — | — | 1 | 4.40 |
| CHEMBL388525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227226 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL227227 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL227224 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL387528 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL227225 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL226546 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL226547 | — | IC50 | = | 31300.0 | nM | 4.50 |
| CHEMBL226595 | — | IC50 | = | 34900.0 | nM | 4.46 |
| CHEMBL387529 | — | IC50 | = | 39900.0 | nM | 4.40 |
| CHEMBL388525 | — | IC50 | = | 160800.0 | nM | - |