Assay Detail
Binding
CHEMBL904294
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Inhibition of human recombinant GST-tagged SIRT2 by histone deacetylase assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
NAD-dependent protein deacetylase sirtuin-2 (CHEMBL4462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An in silico approach to discovering novel inhibitors of human sirtuin type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.24 | 4.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380797 | SIRTINOL | — | 1 | 4.35 |
| CHEMBL425294 | — | — | 1 | 4.25 |
| CHEMBL220458 | — | — | 1 | 4.13 |
| CHEMBL387393 | — | — | 1 | - |
| CHEMBL224844 | — | — | 1 | - |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | - |
| CHEMBL222147 | — | — | 1 | - |
| CHEMBL426391 | — | — | 1 | - |
| CHEMBL222448 | — | — | 1 | - |
| CHEMBL441874 | — | — | 1 | - |
| CHEMBL222502 | — | — | 1 | - |
| CHEMBL225118 | — | — | 1 | - |
| CHEMBL225007 | — | — | 1 | - |
| CHEMBL225082 | — | — | 1 | - |
| CHEMBL385802 | — | — | 1 | - |
| CHEMBL374739 | — | — | 1 | - |
| CHEMBL222495 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380797 | SIRTINOL | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL425294 | — | IC50 | = | 56700.0 | nM | 4.25 |
| CHEMBL220458 | — | IC50 | = | 74300.0 | nM | 4.13 |
| CHEMBL387393 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL224844 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 100500.0 | nM | - |
| CHEMBL222147 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL426391 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL222448 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL441874 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL222502 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL225118 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL225007 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL225082 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL385802 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL374739 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL222495 | — | IC50 | > | 1000000.0 | nM | - |