Assay Detail
Binding
CHEMBL904570
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GST-Cdc25C expressed in Escherichia coli BL21(DE3)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.99 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228419 | — | — | 1 | 5.37 |
| CHEMBL228410 | — | — | 1 | 5.24 |
| CHEMBL389865 | — | — | 1 | 5.07 |
| CHEMBL228420 | — | — | 1 | 5.06 |
| CHEMBL228418 | — | — | 1 | 4.90 |
| CHEMBL228358 | — | — | 1 | 4.27 |
| CHEMBL228356 | — | — | 1 | - |
| CHEMBL376172 | — | — | 1 | - |
| CHEMBL375036 | — | — | 1 | - |
| CHEMBL228357 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228419 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL228410 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL389865 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL228420 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL228418 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL228358 | — | IC50 | = | 53900.0 | nM | 4.27 |
| CHEMBL228356 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL376172 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL375036 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228357 | — | IC50 | > | 100000.0 | nM | - |