Assay Detail
Functional
CHEMBL904573
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Antiviral activity against HIV1 3B in MT4 cells after 4 days by MTT method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.90 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228299 | — | — | 1 | 6.96 |
| CHEMBL426358 | — | — | 1 | 6.82 |
| CHEMBL229101 | — | — | 1 | 6.72 |
| CHEMBL374587 | — | — | 1 | 6.68 |
| CHEMBL229048 | — | — | 1 | 6.66 |
| CHEMBL229049 | — | — | 1 | 6.55 |
| CHEMBL229100 | — | — | 1 | 6.27 |
| CHEMBL229047 | — | — | 1 | 6.15 |
| CHEMBL374588 | — | — | 1 | 6.03 |
| CHEMBL229044 | — | — | 1 | 5.80 |
| CHEMBL229045 | — | — | 1 | 5.68 |
| CHEMBL375924 | — | — | 1 | 5.62 |
| CHEMBL374599 | — | — | 1 | 5.55 |
| CHEMBL228994 | — | — | 1 | 5.40 |
| CHEMBL31871 | HEPT | — | 1 | 5.30 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.27 |
| CHEMBL228298 | — | — | 1 | 5.16 |
| CHEMBL389619 | — | — | 1 | 5.11 |
| CHEMBL228886 | — | — | 1 | 4.38 |
| CHEMBL228885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228299 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL426358 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL229101 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL374587 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL229048 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL229049 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL229100 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL229047 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL374588 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL229044 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL229045 | — | IC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL375924 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL374599 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL228994 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL31871 | HEPT | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL228298 | — | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL389619 | — | IC50 | = | 7690.0 | nM | 5.11 |
| CHEMBL228886 | — | IC50 | = | 41380.0 | nM | 4.38 |
| CHEMBL228885 | — | IC50 | > | 44630.0 | nM | - |