Assay Detail
Binding
CHEMBL904583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK-801 from rat brain NMDA receptor
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
New polyamine-sensitive inhibitors of the NMDA receptor: syntheses and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.48 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229527 | — | — | 1 | 6.51 |
| CHEMBL229102 | — | — | 1 | 6.27 |
| CHEMBL229221 | — | — | 1 | 6.20 |
| CHEMBL425661 | — | — | 1 | 6.13 |
| CHEMBL229528 | — | — | 1 | 6.11 |
| CHEMBL229310 | — | — | 1 | 6.06 |
| CHEMBL229526 | — | — | 1 | 5.98 |
| CHEMBL229312 | — | — | 1 | 5.97 |
| CHEMBL425657 | — | — | 1 | 5.95 |
| CHEMBL389735 | — | — | 1 | 5.92 |
| CHEMBL228825 | — | — | 1 | 5.79 |
| CHEMBL229456 | — | — | 1 | 5.75 |
| CHEMBL229884 | — | — | 1 | 5.66 |
| CHEMBL229279 | — | — | 1 | 5.61 |
| CHEMBL228880 | — | — | 1 | 5.49 |
| CHEMBL229669 | — | — | 1 | 5.38 |
| CHEMBL229246 | — | — | 1 | 5.28 |
| CHEMBL229720 | — | — | 1 | 5.28 |
| CHEMBL229552 | — | — | 1 | 5.28 |
| CHEMBL389701 | — | — | 1 | 5.26 |
| CHEMBL229309 | — | — | 1 | 5.17 |
| CHEMBL388132 | — | — | 1 | 5.17 |
| CHEMBL69590 | — | — | 1 | 5.15 |
| CHEMBL229603 | — | — | 1 | 5.06 |
| CHEMBL229122 | — | — | 1 | 5.02 |
| CHEMBL229939 | — | — | 1 | 4.93 |
| CHEMBL229555 | — | — | 1 | 4.88 |
| CHEMBL229941 | — | — | 1 | 4.87 |
| CHEMBL229455 | — | — | 1 | 4.82 |
| CHEMBL229886 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229527 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL229102 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL229221 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL425661 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL229528 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL229310 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL229526 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL229312 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL425657 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL389735 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL228825 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL229456 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL229884 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL229279 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL228880 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL229669 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL229552 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL229720 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL229246 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL389701 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL229309 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL388132 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL69590 | — | IC50 | = | 7050.0 | nM | 5.15 |
| CHEMBL229603 | — | IC50 | = | 8670.0 | nM | 5.06 |
| CHEMBL229122 | — | IC50 | = | 9620.0 | nM | 5.02 |
| CHEMBL229939 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL229555 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL229941 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL229455 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL229886 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL390140 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL229553 | — | IC50 | = | 358000.0 | nM | - |
| CHEMBL229554 | — | IC50 | = | 114000.0 | nM | - |
| CHEMBL229832 | — | IC50 | = | 282000.0 | nM | - |
| CHEMBL229672 | — | IC50 | = | 111000.0 | nM | - |