Assay Detail
Binding
CHEMBL904584
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Displacement of [3H]MK-801 from NMDA receptor in rat brain in presence of 100 uM spermine
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
New polyamine-sensitive inhibitors of the NMDA receptor: syntheses and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.32 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229603 | — | — | 1 | 6.01 |
| CHEMBL228880 | — | — | 1 | 5.57 |
| CHEMBL229553 | — | — | 1 | 5.55 |
| CHEMBL425657 | — | — | 1 | 5.53 |
| CHEMBL229554 | — | — | 1 | 5.53 |
| CHEMBL228825 | — | — | 1 | 5.41 |
| CHEMBL229312 | — | — | 1 | 5.39 |
| CHEMBL229309 | — | — | 1 | 5.27 |
| CHEMBL229555 | — | — | 1 | 5.18 |
| CHEMBL229246 | — | — | 1 | 5.16 |
| CHEMBL229455 | — | — | 1 | 5.12 |
| CHEMBL229552 | — | — | 1 | 5.11 |
| CHEMBL229310 | — | — | 1 | 5.10 |
| CHEMBL229279 | — | — | 1 | 5.07 |
| CHEMBL229102 | — | — | 1 | 5.05 |
| CHEMBL229221 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229603 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL228880 | — | IC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL229553 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL425657 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL229554 | — | IC50 | = | 2980.0 | nM | 5.53 |
| CHEMBL228825 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL229312 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL229309 | — | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL229555 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL229246 | — | IC50 | = | 6940.0 | nM | 5.16 |
| CHEMBL229455 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL229552 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL229310 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL229279 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL229102 | — | IC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL229221 | — | IC50 | = | 9070.0 | nM | 5.04 |