Assay Detail
Binding
CHEMBL904734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR tyrosine kinase expressed in A431 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.67 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225928 | — | — | 1 | 8.36 |
| CHEMBL225720 | — | — | 1 | 7.43 |
| CHEMBL225929 | — | — | 1 | 7.15 |
| CHEMBL343352 | — | — | 1 | 6.70 |
| CHEMBL225721 | — | — | 1 | 6.01 |
| CHEMBL225930 | — | — | 1 | 5.66 |
| CHEMBL388286 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225928 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL225720 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL225929 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL343352 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL225721 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL225930 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL388286 | — | IC50 | = | 3960.0 | nM | 5.40 |