Assay Detail
Functional
CHEMBL904736
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serum-stimulated growth of NIH3T3 cells after 3 days by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.64 | 5.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388286 | — | — | 1 | 5.04 |
| CHEMBL225929 | — | — | 1 | 4.82 |
| CHEMBL225721 | — | — | 1 | 4.67 |
| CHEMBL225928 | — | — | 1 | 4.57 |
| CHEMBL225930 | — | — | 1 | 4.56 |
| CHEMBL343352 | — | — | 1 | 4.42 |
| CHEMBL225720 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388286 | — | IC50 | = | 9068.0 | nM | 5.04 |
| CHEMBL225929 | — | IC50 | = | 15190.0 | nM | 4.82 |
| CHEMBL225721 | — | IC50 | = | 21530.0 | nM | 4.67 |
| CHEMBL225928 | — | IC50 | = | 27180.0 | nM | 4.57 |
| CHEMBL225930 | — | IC50 | = | 27560.0 | nM | 4.56 |
| CHEMBL343352 | — | IC50 | = | 38380.0 | nM | 4.42 |
| CHEMBL225720 | — | IC50 | = | 39500.0 | nM | 4.40 |