Assay Detail
Functional
CHEMBL904737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of serum-stimulated growth of NIH3T3 cells transfected with HER14 after 3 days by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel nitrogen mustard-armed combi-molecules for the selective targeting of epidermal growth factor receptor overexperessing solid tumors: discovery of an unusual structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225928 | — | — | 1 | 5.88 |
| CHEMBL225720 | — | — | 1 | 5.78 |
| CHEMBL225929 | — | — | 1 | 5.53 |
| CHEMBL343352 | — | — | 1 | 5.50 |
| CHEMBL225721 | — | — | 1 | 5.24 |
| CHEMBL388286 | — | — | 1 | 5.21 |
| CHEMBL225930 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225928 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL225720 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL225929 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL343352 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL225721 | — | IC50 | = | 5750.0 | nM | 5.24 |
| CHEMBL388286 | — | IC50 | = | 6224.0 | nM | 5.21 |
| CHEMBL225930 | — | IC50 | = | 11950.0 | nM | 4.92 |