Assay Detail
Functional
CHEMBL904866
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Antiproliferative activity against human BT474 cells by MTS assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.08 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.00 |
| CHEMBL389164 | — | — | 1 | 7.52 |
| CHEMBL229943 | — | — | 1 | 7.30 |
| CHEMBL536072 | — | — | 1 | 7.30 |
| CHEMBL229576 | — | — | 1 | 7.10 |
| CHEMBL229577 | — | — | 1 | 7.05 |
| CHEMBL557165 | — | — | 1 | 7.00 |
| CHEMBL376166 | — | — | 1 | 7.00 |
| CHEMBL229839 | — | — | 1 | 6.82 |
| CHEMBL229891 | — | — | 1 | 6.52 |
| CHEMBL388347 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL389164 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL229943 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL536072 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL229576 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL229577 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL557165 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL376166 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL229839 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL229891 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL388347 | — | IC50 | = | 500.0 | nM | 6.30 |