Assay Detail
Functional
CHEMBL904912
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Antiproliferative activity against HMVE cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMVE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.59 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | — | 1 | 7.00 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | — | 1 | 6.52 |
| CHEMBL176252 | — | — | 1 | 6.52 |
| CHEMBL118143 | — | — | 1 | 6.30 |
| CHEMBL225848 | — | — | 1 | - |
| CHEMBL77961 | — | — | 1 | - |
| CHEMBL225847 | — | — | 1 | - |
| CHEMBL388758 | — | — | 1 | - |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442016 | ADAROTENE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1180 | O-DEMETHYLATED ADAPALENE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL176252 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL118143 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL225848 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL77961 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL225847 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL388758 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL38 | TRETINOIN | IC50 | > | 500.0 | nM | - |