Assay Detail
Binding
CHEMBL904952
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Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat cortical tissue
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.54 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558182 | — | — | 1 | 7.55 |
| CHEMBL556365 | — | — | 1 | 7.55 |
| CHEMBL553714 | — | — | 1 | 7.22 |
| CHEMBL537874 | — | — | 1 | 7.20 |
| CHEMBL541896 | — | — | 1 | 7.12 |
| CHEMBL534501 | — | — | 1 | 7.00 |
| CHEMBL558395 | — | — | 1 | 6.99 |
| CHEMBL537206 | — | — | 1 | 6.86 |
| CHEMBL559186 | — | — | 1 | 6.80 |
| CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | 4.0 | 1 | 6.57 |
| CHEMBL558394 | — | — | 1 | 6.55 |
| CHEMBL557356 | — | — | 1 | 6.46 |
| CHEMBL537652 | — | — | 1 | 6.43 |
| CHEMBL537875 | — | — | 1 | 6.39 |
| CHEMBL556366 | — | — | 1 | 6.27 |
| CHEMBL541895 | — | — | 1 | 6.16 |
| CHEMBL540625 | — | — | 1 | 5.82 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | 4.0 | 1 | 5.71 |
| CHEMBL1203942 | — | — | 1 | 5.69 |
| CHEMBL537429 | — | — | 1 | 5.56 |
| CHEMBL541134 | — | — | 1 | 5.39 |
| CHEMBL54134 | — | — | 1 | - |
| CHEMBL553859 | — | — | 1 | - |
| CHEMBL534500 | — | — | 1 | - |
| CHEMBL537654 | — | — | 1 | - |
| CHEMBL537653 | — | — | 1 | - |
| CHEMBL537431 | — | — | 1 | - |
| CHEMBL537209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558182 | — | Ki | = | 27.9 | nM | 7.55 |
| CHEMBL556365 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL553714 | — | Ki | = | 60.8 | nM | 7.22 |
| CHEMBL537874 | — | Ki | = | 63.7 | nM | 7.20 |
| CHEMBL541896 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL534501 | — | Ki | = | 98.8 | nM | 7.00 |
| CHEMBL558395 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL537206 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL559186 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL558394 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL557356 | — | Ki | = | 351.0 | nM | 6.46 |
| CHEMBL537652 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL537875 | — | Ki | = | 411.0 | nM | 6.39 |
| CHEMBL556366 | — | Ki | = | 534.0 | nM | 6.27 |
| CHEMBL541895 | — | Ki | = | 694.0 | nM | 6.16 |
| CHEMBL540625 | — | Ki | = | 1520.0 | nM | 5.82 |
| CHEMBL529437 | COCAINE HYDROCHLORIDE | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL1203942 | — | Ki | = | 2040.0 | nM | 5.69 |
| CHEMBL537429 | — | Ki | = | 2750.0 | nM | 5.56 |
| CHEMBL541134 | — | Ki | = | 4030.0 | nM | 5.39 |
| CHEMBL54134 | — | Ki | - | — | - | |
| CHEMBL553859 | — | Ki | - | — | - | |
| CHEMBL534500 | — | Ki | - | — | - | |
| CHEMBL537654 | — | Ki | - | — | - | |
| CHEMBL537653 | — | Ki | - | — | - | |
| CHEMBL537431 | — | Ki | - | — | - | |
| CHEMBL537209 | — | Ki | - | — | - |