Assay Detail
Functional
CHEMBL905037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5.0 ug/mL collagen-induced platelet aggregation in human platelet rich plasma
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.38 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228776 | — | — | 1 | 6.55 |
| CHEMBL228617 | — | — | 1 | 6.36 |
| CHEMBL229417 | — | — | 1 | 6.29 |
| CHEMBL228618 | — | — | 1 | 6.10 |
| CHEMBL388774 | — | — | 1 | 5.96 |
| CHEMBL228614 | — | — | 1 | 5.89 |
| CHEMBL229362 | — | — | 1 | 5.75 |
| CHEMBL228726 | — | — | 1 | 5.72 |
| CHEMBL229243 | — | — | 1 | 5.72 |
| CHEMBL388203 | — | — | 1 | 5.68 |
| CHEMBL387776 | — | — | 1 | 5.59 |
| CHEMBL388548 | — | — | 1 | 5.44 |
| CHEMBL228668 | — | — | 1 | 5.42 |
| CHEMBL228778 | — | — | 1 | 5.38 |
| CHEMBL228619 | — | — | 1 | 5.19 |
| CHEMBL228613 | — | — | 1 | 5.18 |
| CHEMBL228669 | — | — | 1 | 5.15 |
| CHEMBL228777 | — | — | 1 | 5.11 |
| CHEMBL229956 | — | — | 1 | 5.06 |
| CHEMBL375726 | — | — | 1 | 4.98 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 4.92 |
| CHEMBL387991 | — | — | 1 | 4.74 |
| CHEMBL229568 | — | — | 1 | 4.62 |
| CHEMBL442062 | — | — | 1 | 4.47 |
| CHEMBL799 | CILOSTAZOL | 4.0 | 1 | 4.40 |
| CHEMBL228779 | — | — | 1 | 4.14 |
| CHEMBL612001 | — | — | 1 | - |
| CHEMBL228729 | — | — | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
| CHEMBL229566 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228776 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL228617 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL229417 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL228618 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL388774 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL228614 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL229362 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL228726 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL229243 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL388203 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL387776 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL388548 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL228668 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL228778 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL228619 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL228613 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL228669 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL228777 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL229956 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL375726 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL189 | MILRINONE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL387991 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL229568 | — | IC50 | = | 24200.0 | nM | 4.62 |
| CHEMBL442062 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL228779 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL612001 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL228729 | — | IC50 | = | 169000.0 | nM | - |
| CHEMBL25 | ASPIRIN | IC50 | = | 183000.0 | nM | - |
| CHEMBL229566 | — | IC50 | = | 144000.0 | nM | - |
| CHEMBL375923 | — | IC50 | = | 169000.0 | nM | - |