Assay Detail
Functional
CHEMBL905039
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Inhibition of A23187-induced platelet aggregation in human platelet rich plasma
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.11 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229362 | — | — | 1 | 5.96 |
| CHEMBL229417 | — | — | 1 | 5.85 |
| CHEMBL228618 | — | — | 1 | 5.82 |
| CHEMBL388774 | — | — | 1 | 5.72 |
| CHEMBL228776 | — | — | 1 | 5.60 |
| CHEMBL228617 | — | — | 1 | 5.47 |
| CHEMBL228614 | — | — | 1 | 5.46 |
| CHEMBL229243 | — | — | 1 | 5.30 |
| CHEMBL388203 | — | — | 1 | 5.24 |
| CHEMBL228726 | — | — | 1 | 5.24 |
| CHEMBL387776 | — | — | 1 | 5.11 |
| CHEMBL228669 | — | — | 1 | 4.97 |
| CHEMBL229956 | — | — | 1 | 4.89 |
| CHEMBL375726 | — | — | 1 | 4.88 |
| CHEMBL228668 | — | — | 1 | 4.86 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 4.85 |
| CHEMBL228778 | — | — | 1 | 4.84 |
| CHEMBL228619 | — | — | 1 | 4.79 |
| CHEMBL228613 | — | — | 1 | 4.72 |
| CHEMBL388548 | — | — | 1 | 4.72 |
| CHEMBL228777 | — | — | 1 | 4.64 |
| CHEMBL387991 | — | — | 1 | 4.44 |
| CHEMBL229568 | — | — | 1 | 4.10 |
| CHEMBL229518 | — | — | 1 | - |
| CHEMBL442062 | — | — | 1 | - |
| CHEMBL229566 | — | — | 1 | - |
| CHEMBL612001 | — | — | 1 | - |
| CHEMBL228729 | — | — | 1 | - |
| CHEMBL375923 | — | — | 1 | - |
| CHEMBL228779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229362 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL229417 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL228618 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL388774 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL228776 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL228617 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL228614 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL229243 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL388203 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL228726 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL387776 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL228669 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL229956 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL375726 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL228668 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL189 | MILRINONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL228778 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL228619 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL228613 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL388548 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL228777 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL387991 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL229568 | — | IC50 | = | 78800.0 | nM | 4.10 |
| CHEMBL229518 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL442062 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL229566 | — | IC50 | = | 429000.0 | nM | - |
| CHEMBL612001 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL228729 | — | IC50 | = | 175000.0 | nM | - |
| CHEMBL375923 | — | IC50 | = | 218800.0 | nM | - |
| CHEMBL228779 | — | IC50 | = | 163000.0 | nM | - |
| CHEMBL25 | ASPIRIN | IC50 | > | 1000000.0 | nM | - |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 109000.0 | nM | - |
| CHEMBL229619 | — | IC50 | = | 240000.0 | nM | - |