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Assay Detail

CHEMBL905128

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CGP-12177 from beta-1 adrenergic receptor in Sprague-Dawley rat cortical membrane
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Beta-1 adrenergic receptor (CHEMBL3252)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao RP, Abernethy DR, Wainer IW.
J Med Chem (2007) 50 : 2903 -2915
PubMed 17506540 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 26 4.58 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL229401 1 5.47
CHEMBL425658 1 4.99
CHEMBL388570 1 4.83
CHEMBL229614 1 4.80
CHEMBL229391 1 4.76
CHEMBL229476 1 4.72
CHEMBL228992 1 4.66
CHEMBL389629 1 4.60
CHEMBL228996 1 4.51
CHEMBL229388 1 4.50
CHEMBL229390 1 4.50
CHEMBL229442 1 4.48
CHEMBL228998 1 4.48
CHEMBL388177 1 4.46
CHEMBL229620 1 4.37
CHEMBL389734 1 4.28
CHEMBL389902 1 4.28
CHEMBL229616 1 4.21
CHEMBL387825 1 4.11
CHEMBL229443 1 -
CHEMBL229400 1 -
CHEMBL389519 1 -
CHEMBL229615 1 -
CHEMBL228417 1 -
CHEMBL389390 1 -
CHEMBL229477 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL229401 Ki = 3350.0 nM 5.47
CHEMBL425658 Ki = 10200.0 nM 4.99
CHEMBL388570 Ki = 14800.0 nM 4.83
CHEMBL229614 Ki = 15800.0 nM 4.80
CHEMBL229391 Ki = 17200.0 nM 4.76
CHEMBL229476 Ki = 18900.0 nM 4.72
CHEMBL228992 Ki = 21900.0 nM 4.66
CHEMBL389629 Ki = 24900.0 nM 4.60
CHEMBL228996 Ki = 30800.0 nM 4.51
CHEMBL229388 Ki = 31300.0 nM 4.50
CHEMBL229390 Ki = 31400.0 nM 4.50
CHEMBL229442 Ki = 33100.0 nM 4.48
CHEMBL228998 Ki = 33400.0 nM 4.48
CHEMBL388177 Ki = 34700.0 nM 4.46
CHEMBL229620 Ki = 42500.0 nM 4.37
CHEMBL389734 Ki = 52600.0 nM 4.28
CHEMBL389902 Ki = 52200.0 nM 4.28
CHEMBL229616 Ki = 61300.0 nM 4.21
CHEMBL387825 Ki = 77500.0 nM 4.11
CHEMBL229443 Ki > 100000.0 nM -
CHEMBL229400 Ki > 100000.0 nM -
CHEMBL389519 Ki > 100000.0 nM -
CHEMBL229615 Ki > 100000.0 nM -
CHEMBL228417 Ki > 100000.0 nM -
CHEMBL389390 Ki > 100000.0 nM -
CHEMBL229477 Ki > 100000.0 nM -