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Assay Detail

CHEMBL905129

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]CGP12177 from human beta-2 adrenergic receptor expressed in HEK293 cells
ChEMBL ↗
52
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Expert

Target

Beta-2 adrenergic receptor (CHEMBL210) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.
Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao RP, Abernethy DR, Wainer IW.
J Med Chem (2007) 50 : 2903 -2915
PubMed 17506540 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 52 5.23 6.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL229401 — — 2 6.62
CHEMBL229614 — — 2 6.47
CHEMBL388570 — — 2 6.46
CHEMBL228992 — — 2 6.33
CHEMBL388177 — — 2 5.75
CHEMBL229391 — — 2 5.73
CHEMBL228996 — — 2 5.71
CHEMBL389519 — — 2 5.60
CHEMBL389629 — — 2 5.53
CHEMBL229476 — — 2 5.43
CHEMBL228998 — — 2 5.28
CHEMBL229442 — — 2 5.22
CHEMBL229388 — — 2 5.10
CHEMBL425658 — — 2 5.03
CHEMBL229477 — — 2 4.99
CHEMBL229620 — — 2 4.98
CHEMBL228417 — — 2 4.80
CHEMBL389902 — — 2 4.69
CHEMBL387825 — — 2 4.64
CHEMBL389390 — — 2 4.56
CHEMBL229400 — — 2 4.54
CHEMBL229390 — — 2 4.54
CHEMBL229443 — — 2 4.51
CHEMBL229615 — — 2 4.50
CHEMBL389734 — — 2 4.25
CHEMBL229616 — — 2 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL229401 — Ki = 239.88 nM 6.62
CHEMBL229401 — Ki = 240.0 nM 6.62
CHEMBL229614 — Ki = 340.0 nM 6.47
CHEMBL229614 — Ki = 338.84 nM 6.47
CHEMBL388570 — Ki = 346.74 nM 6.46
CHEMBL388570 — Ki = 350.0 nM 6.46
CHEMBL228992 — Ki = 470.0 nM 6.33
CHEMBL228992 — Ki = 478.63 nM 6.32
CHEMBL388177 — Ki = 1780.0 nM 5.75
CHEMBL388177 — Ki = 1778.28 nM 5.75
CHEMBL229391 — Ki = 1862.09 nM 5.73
CHEMBL229391 — Ki = 1860.0 nM 5.73
CHEMBL228996 — Ki = 1930.0 nM 5.71
CHEMBL228996 — Ki = 1949.84 nM 5.71
CHEMBL389519 — Ki = 2511.89 nM 5.60
CHEMBL389519 — Ki = 2540.0 nM 5.59
CHEMBL389629 — Ki = 2951.21 nM 5.53
CHEMBL389629 — Ki = 2930.0 nM 5.53
CHEMBL229476 — Ki = 3690.0 nM 5.43
CHEMBL229476 — Ki = 3715.35 nM 5.43
CHEMBL228998 — Ki = 5248.07 nM 5.28
CHEMBL228998 — Ki = 5270.0 nM 5.28
CHEMBL229442 — Ki = 6040.0 nM 5.22
CHEMBL229442 — Ki = 6025.6 nM 5.22
CHEMBL229388 — Ki = 7943.28 nM 5.10
CHEMBL229388 — Ki = 7940.0 nM 5.10
CHEMBL425658 — Ki = 9280.0 nM 5.03
CHEMBL425658 — Ki = 9332.54 nM 5.03
CHEMBL229477 — Ki = 10232.93 nM 4.99
CHEMBL229477 — Ki = 10300.0 nM 4.99
CHEMBL229620 — Ki = 10500.0 nM 4.98
CHEMBL229620 — Ki = 10471.29 nM 4.98
CHEMBL228417 — Ki = 15848.93 nM 4.80
CHEMBL228417 — Ki = 15900.0 nM 4.80
CHEMBL389902 — Ki = 20600.0 nM 4.69
CHEMBL389902 — Ki = 20417.38 nM 4.69
CHEMBL387825 — Ki = 23100.0 nM 4.64
CHEMBL387825 — Ki = 22908.68 nM 4.64
CHEMBL389390 — Ki = 27800.0 nM 4.56
CHEMBL389390 — Ki = 27542.29 nM 4.56
CHEMBL229390 — Ki = 28840.32 nM 4.54
CHEMBL229390 — Ki = 28600.0 nM 4.54
CHEMBL229400 — Ki = 28840.32 nM 4.54
CHEMBL229400 — Ki = 28800.0 nM 4.54
CHEMBL229443 — Ki = 30902.95 nM 4.51
CHEMBL229443 — Ki = 30800.0 nM 4.51
CHEMBL229615 — Ki = 31400.0 nM 4.50
CHEMBL229615 — Ki = 31622.78 nM 4.50
CHEMBL389734 — Ki = 56234.13 nM 4.25
CHEMBL389734 — Ki = 56420.0 nM 4.25