Assay Detail
Functional
CHEMBL905186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mu opioid receptor expressed in HN9.10 cells assessed by [35S]GTP-gamma-S binding assay
18
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 7.26 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439019 | — | — | 2 | 7.56 |
| CHEMBL389652 | — | — | 2 | 7.50 |
| CHEMBL389651 | — | — | 2 | 7.48 |
| CHEMBL229280 | — | — | 2 | 7.47 |
| CHEMBL38874 | DAMGO | — | 2 | 7.44 |
| CHEMBL426363 | — | — | 2 | 7.38 |
| CHEMBL2371977 | — | — | 2 | 7.23 |
| CHEMBL387670 | — | — | 2 | 6.82 |
| CHEMBL2371978 | — | — | 2 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439019 | — | EC50 | = | 27.54 | nM | 7.56 |
| CHEMBL439019 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL389652 | — | EC50 | = | 31.62 | nM | 7.50 |
| CHEMBL389652 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL389651 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL389651 | — | EC50 | = | 33.11 | nM | 7.48 |
| CHEMBL229280 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL229280 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL38874 | DAMGO | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL38874 | DAMGO | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL426363 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL426363 | — | EC50 | = | 41.69 | nM | 7.38 |
| CHEMBL2371977 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL2371977 | — | EC50 | = | 58.88 | nM | 7.23 |
| CHEMBL387670 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL387670 | — | EC50 | = | 151.36 | nM | 6.82 |
| CHEMBL2371978 | — | EC50 | = | 346.74 | nM | 6.46 |
| CHEMBL2371978 | — | EC50 | = | 350.0 | nM | 6.46 |