Assay Detail
Functional
CHEMBL905189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at delta opioid receptor in ICR mouse vas deferens assessed as inhibition of electrically-stimulated muscle contraction
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.40 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 9.57 |
| CHEMBL200199 | BIPHALIN | — | 1 | 8.57 |
| CHEMBL439019 | — | — | 1 | 7.77 |
| CHEMBL389652 | — | — | 1 | 7.66 |
| CHEMBL229280 | — | — | 1 | 7.48 |
| CHEMBL389651 | — | — | 1 | 7.00 |
| CHEMBL426363 | — | — | 1 | 6.77 |
| CHEMBL387670 | — | — | 1 | 6.72 |
| CHEMBL2371978 | — | — | 1 | 6.39 |
| CHEMBL2371977 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL200199 | BIPHALIN | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL439019 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL389652 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL229280 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL389651 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL426363 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL387670 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2371978 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2371977 | — | IC50 | = | 910.0 | nM | 6.04 |