Assay Detail
Functional
CHEMBL905190
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mu opioid receptor in Hartley guinea pig ileum assessed as inhibition of electrically-stimulated muscle contraction
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 1 | 8.06 |
| CHEMBL340032 | DADLE | — | 1 | 7.62 |
| CHEMBL229280 | — | — | 1 | 6.82 |
| CHEMBL389651 | — | — | 1 | 6.47 |
| CHEMBL389652 | — | — | 1 | 6.44 |
| CHEMBL439019 | — | — | 1 | 6.43 |
| CHEMBL426363 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL340032 | DADLE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL229280 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL389651 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL389652 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL439019 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL426363 | — | IC50 | = | 380.0 | nM | 6.42 |