Assay Detail
Binding
CHEMBL905312
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Inhibition of Sprague-Dawley rat spleen microsome HO1
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.87 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL536746 | — | — | 1 | 7.22 |
| CHEMBL540883 | — | — | 1 | 6.96 |
| CHEMBL536745 | — | — | 1 | 6.85 |
| CHEMBL538578 | — | — | 1 | 6.30 |
| CHEMBL558183 | — | — | 1 | 6.16 |
| CHEMBL536518 | — | — | 1 | 5.85 |
| CHEMBL537207 | — | — | 1 | 5.77 |
| CHEMBL539857 | — | — | 1 | 5.72 |
| CHEMBL541386 | — | — | 1 | 5.57 |
| CHEMBL536517 | — | — | 1 | 5.43 |
| CHEMBL540111 | — | — | 1 | 5.42 |
| CHEMBL536514 | — | — | 1 | 5.40 |
| CHEMBL541899 | — | — | 1 | 5.37 |
| CHEMBL552737 | — | — | 1 | 5.33 |
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 5.28 |
| CHEMBL536516 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL536746 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL540883 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL536745 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL538578 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL558183 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL536518 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL537207 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL539857 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL541386 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL536517 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL540111 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL536514 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL541899 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL552737 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL70611 | AZALANSTAT | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL536516 | — | IC50 | = | 6200.0 | nM | 5.21 |