Assay Detail
Functional
CHEMBL905320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B-induced cytopathic effect in MT4 cells assessed as inhibition of virus-induced syncytium formation
38
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390110 | — | — | 2 | 7.70 |
| CHEMBL390956 | — | — | 2 | 7.52 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 6.46 |
| CHEMBL224865 | — | — | 2 | 6.40 |
| CHEMBL296175 | — | — | 1 | 6.22 |
| CHEMBL376552 | — | — | 2 | 6.00 |
| CHEMBL226271 | — | — | 2 | 5.89 |
| CHEMBL389909 | — | — | 2 | 5.41 |
| CHEMBL225798 | — | — | 2 | 5.37 |
| CHEMBL225969 | — | — | 2 | 5.37 |
| CHEMBL376385 | — | — | 2 | 5.30 |
| CHEMBL226272 | — | — | 2 | 5.21 |
| CHEMBL226116 | — | — | 2 | 5.19 |
| CHEMBL225970 | — | — | 2 | 4.59 |
| CHEMBL227510 | — | — | 2 | - |
| CHEMBL376553 | — | — | 2 | - |
| CHEMBL227509 | — | — | 2 | - |
| CHEMBL225747 | — | — | 2 | - |
| CHEMBL375705 | — | — | 2 | - |
| CHEMBL390122 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390110 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL390956 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL224865 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL296175 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL376552 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL226271 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL389909 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL225969 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL225798 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL376385 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL226272 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL226116 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL225970 | — | EC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL227510 | — | EC50 | > | 167200.0 | nM | - |
| CHEMBL376553 | — | EC50 | > | 242500.0 | nM | - |
| CHEMBL227509 | — | EC50 | > | 194800.0 | nM | - |
| CHEMBL225747 | — | EC50 | > | 122800.0 | nM | - |
| CHEMBL375705 | — | EC50 | > | 10800.0 | nM | - |
| CHEMBL390122 | — | EC50 | > | 80200.0 | nM | - |
| CHEMBL225970 | — | EC50 | = | 39810717055349.7 | nM | - |
| CHEMBL376552 | — | EC50 | = | 1000000000000000.0 | nM | - |
| CHEMBL226271 | — | EC50 | = | 794328234724282.1 | nM | - |
| CHEMBL376385 | — | EC50 | = | 199526231496888.28 | nM | - |
| CHEMBL226272 | — | EC50 | = | 158489319246111.1 | nM | - |
| CHEMBL389909 | — | EC50 | = | 251188643150958.22 | nM | - |
| CHEMBL225798 | — | EC50 | = | 251188643150958.22 | nM | - |
| CHEMBL224865 | — | EC50 | = | 2511886431509582.0 | nM | - |
| CHEMBL390110 | — | EC50 | = | 3.981071705534986e+16 | nM | - |
| CHEMBL390956 | — | EC50 | = | 3.981071705534986e+16 | nM | - |
| CHEMBL227510 | — | EC50 | = | 3162277660168.38 | nM | - |
| CHEMBL225969 | — | EC50 | = | 251188643150958.22 | nM | - |
| CHEMBL376553 | — | EC50 | = | 1995262314968.88 | nM | - |
| CHEMBL227509 | — | EC50 | = | 2511886431509.58 | nM | - |
| CHEMBL225747 | — | EC50 | = | 3981071705534.97 | nM | - |
| CHEMBL375705 | — | EC50 | = | 50118723362727.15 | nM | - |
| CHEMBL390122 | — | EC50 | = | 6309573444801.94 | nM | - |
| CHEMBL226116 | — | EC50 | = | 158489319246111.1 | nM | - |