Assay Detail
Functional
CHEMBL905325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B-induced cytopathic effect in CEM cells assessed as inhibition of virus-induced syncytium formation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.90 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390110 | — | — | 1 | 7.70 |
| CHEMBL390956 | — | — | 1 | 7.70 |
| CHEMBL224865 | — | — | 1 | 6.52 |
| CHEMBL376552 | — | — | 1 | 6.10 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | — | 1 | 5.96 |
| CHEMBL226271 | — | — | 1 | 5.96 |
| CHEMBL225798 | — | — | 1 | 5.42 |
| CHEMBL389909 | — | — | 1 | 5.41 |
| CHEMBL225969 | — | — | 1 | 5.39 |
| CHEMBL376385 | — | — | 1 | 5.36 |
| CHEMBL226116 | — | — | 1 | 5.25 |
| CHEMBL226272 | — | — | 1 | 5.24 |
| CHEMBL225970 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390110 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL390956 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL224865 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL376552 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL53554 | THIAZOLOBENZIMIDAZOLE | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL226271 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL225798 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL389909 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL225969 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL376385 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL226116 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL226272 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL225970 | — | EC50 | = | 20300.0 | nM | 4.69 |