Assay Detail
Binding
CHEMBL905368
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Inhibition of human xanthine oxidase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.61 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1467 | ALLOPURINOL | 4.0 | 1 | 5.11 |
| CHEMBL446449 | — | — | 1 | 4.99 |
| CHEMBL226345 | ADENINE | 3.0 | 1 | 4.96 |
| CHEMBL388593 | — | — | 1 | 4.52 |
| CHEMBL164921 | — | — | 1 | 4.06 |
| CHEMBL727 | THIOGUANINE | 4.0 | 1 | 4.03 |
| CHEMBL388594 | 2-AMINOPURINE | — | 1 | - |
| CHEMBL351132 | DIMEDAZOL | — | 1 | - |
| CHEMBL388596 | 2,6-DIAMINOPURINE | — | 1 | - |
| CHEMBL157729 | — | — | 1 | - |
| CHEMBL226396 | 6-CHLOROGUANINE | — | 1 | - |
| CHEMBL226395 | METHYLGUANINE | — | 1 | - |
| CHEMBL1250 | 1-METHYLXANTHINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1467 | ALLOPURINOL | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL446449 | — | IC50 | = | 10190.0 | nM | 4.99 |
| CHEMBL226345 | ADENINE | IC50 | = | 10890.0 | nM | 4.96 |
| CHEMBL388593 | — | IC50 | = | 30260.0 | nM | 4.52 |
| CHEMBL164921 | — | IC50 | = | 86840.0 | nM | 4.06 |
| CHEMBL727 | THIOGUANINE | IC50 | = | 92420.0 | nM | 4.03 |
| CHEMBL388594 | 2-AMINOPURINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL351132 | DIMEDAZOL | IC50 | > | 200000.0 | nM | - |
| CHEMBL388596 | 2,6-DIAMINOPURINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL157729 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL226396 | 6-CHLOROGUANINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL226395 | METHYLGUANINE | IC50 | > | 200000.0 | nM | - |
| CHEMBL1250 | 1-METHYLXANTHINE | IC50 | > | 200000.0 | nM | - |