Assay Detail
Binding
CHEMBL905524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
9
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.55 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390718 | — | — | 3 | 10.00 |
| CHEMBL318235 | — | — | 3 | 9.57 |
| CHEMBL226636 | — | — | 3 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390718 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL318235 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL318235 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL390718 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL226636 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL390718 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL318235 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL226636 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL226636 | — | Ki | = | 72.0 | nM | 7.14 |