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Assay Detail

CHEMBL906265

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Binding
Inhibition of tubulin polymerization
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin (CHEMBL2095182)
Type PROTEIN COMPLEX GROUP
Organism Homo sapiens

Publication

Highly potent triazole-based tubulin polymerization inhibitors.
Zhang Q, Peng Y, Wang XI, Keenan SM, Arora S, Welsh WJ.
J Med Chem (2007) 50 : 749 -754
PubMed 17249649 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.32 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL375206 1 5.52
CHEMBL221628 1 5.39
CHEMBL414531 1 5.25
CHEMBL67 COMBRETASTATIN A4 -1.0 1 5.24
CHEMBL376708 1 5.22
CHEMBL374568 1 -
CHEMBL428647 PACLITAXEL 4.0 1 -
CHEMBL107 COLCHICINE 4.0 1 -
CHEMBL220694 1 -
CHEMBL386960 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL375206 IC50 = 3000.0 nM 5.52
CHEMBL221628 IC50 = 4100.0 nM 5.39
CHEMBL414531 IC50 = 5600.0 nM 5.25
CHEMBL67 COMBRETASTATIN A4 IC50 = 5800.0 nM 5.24
CHEMBL376708 IC50 = 6000.0 nM 5.22
CHEMBL374568 IC50 - -
CHEMBL428647 PACLITAXEL IC50 - -
CHEMBL107 COLCHICINE IC50 - -
CHEMBL220694 IC50 - -
CHEMBL386960 IC50 > 10000.0 nM -