Assay Detail
Binding
CHEMBL906324
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Displacement of [3H]PGE2 from human recombinant EP1 receptor expressed in CHOK1 cell membrane
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 8.45 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL387969 | — | — | 1 | 9.40 |
| CHEMBL228586 | — | — | 1 | 9.40 |
| CHEMBL387878 | — | — | 1 | 9.20 |
| CHEMBL228593 | — | — | 1 | 9.10 |
| CHEMBL228963 | — | — | 1 | 8.90 |
| CHEMBL230765 | — | — | 1 | 8.90 |
| CHEMBL395248 | — | — | 1 | 8.90 |
| CHEMBL395488 | — | — | 1 | 8.70 |
| CHEMBL426913 | — | — | 1 | 8.70 |
| CHEMBL230766 | — | — | 1 | 8.70 |
| CHEMBL228638 | — | — | 1 | 8.70 |
| CHEMBL414978 | — | — | 1 | 8.60 |
| CHEMBL230875 | — | — | 1 | 8.60 |
| CHEMBL397655 | — | — | 1 | 8.60 |
| CHEMBL388294 | — | — | 1 | 8.50 |
| CHEMBL228644 | — | — | 1 | 8.40 |
| CHEMBL228592 | — | — | 1 | 8.40 |
| CHEMBL228746 | — | — | 1 | 8.30 |
| CHEMBL231184 | — | — | 1 | 8.30 |
| CHEMBL374824 | — | — | 1 | 8.30 |
| CHEMBL228695 | — | — | 1 | 8.20 |
| CHEMBL208791 | — | — | 2 | 8.20 |
| CHEMBL388478 | — | — | 1 | 8.10 |
| CHEMBL390081 | — | — | 1 | 7.90 |
| CHEMBL230874 | — | — | 1 | 7.90 |
| CHEMBL388510 | — | — | 1 | 7.80 |
| CHEMBL230873 | — | — | 1 | 7.80 |
| CHEMBL397226 | — | — | 1 | 7.60 |
| CHEMBL269514 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL387969 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL228586 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL387878 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL228593 | — | IC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL228963 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL230765 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL395248 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL426913 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL230766 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL395488 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL228638 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL230875 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL397655 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL414978 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL388294 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL228644 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL228592 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL374824 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL228746 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL231184 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL208791 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL228695 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL208791 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL388478 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL390081 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL230874 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL230873 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL388510 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL397226 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL269514 | — | IC50 | = | 79.43 | nM | 7.10 |