Assay Detail
Binding
CHEMBL906334
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Displacement of [11C]PK-11195 from PBR in Sprague-Dawley rat brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.13 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63064 | — | — | 1 | 8.89 |
| CHEMBL220641 | — | — | 1 | 8.36 |
| CHEMBL481537 | PK-11195 | — | 1 | 8.04 |
| CHEMBL220642 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63064 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL220641 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL481537 | PK-11195 | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL220642 | — | IC50 | = | 60.1 | nM | 7.22 |